FRICTION TEST AND PARAMETER ANALYSIS OF PRESTRESSED CONCRETE CONTINUOUS BEAM BRIDGE

The prestressed ducts of prestressed concrete continuous girder bridges are usually three-dimensionally distributed and long in length. The control of prestress loss during construction is very important. In order to ensure the effect of prestress tensioning, the test and analysis of friction parameters of prestressed ducts are particularly important. Based on the tension process of a prestressed concrete continuous beam bridge, the initial tension stress, loading time and channel friction parameters of the prestressed concrete continuous beam bridge are tested by field tests. Combined with the measured friction parameters, the finite element software Midas / Civil is used to analyse the influence of friction parameters on the mechanical properties of prestressed concrete continuous beam bridge. The results show that when the prestressed steel with bending angle not more than 40° and length not more than 70 m is stretched, the initial tension stress is suggested to be set as 20 % of the tension control force and the loading time is 5 min. The measured tunnel friction parameters are larger than the standard value, and the tension control force should be adjusted during the formal tension construction；The deflection of the key section of the main beam increases with the increase of the friction parameters, and the roof stress decreases with the increase of the friction parameters. The change of channel deviation coefficient has a greater impact on the deflection and roof stress than the change of friction coefficient

Short video marketing : what, when and how short-branded videos facilitate consumer engagement

Purpose This study explores whether and how four main factors of short-branded video content (content matching, information relevance, storytelling and emotionality) facilitate consumer engagement (likes, comments and shares), as well as the moderating effect of the release time (morning, afternoon and evening) in such relationships. Design/methodology/approach This study uses Python to write programs to crawl relevant data information, such as consumer engagement and short video release time. It combines coding methods to empirically analyze the impact of short-branded video content characteristics on consumer engagement. A total of 10,240 Weibo short videos (total duration: 238.645 h) from 122 well-known brands are utilized as research objects. Findings Empirical results show that the content characteristics of short videos significantly affected consumer engagement. Furthermore, the release time of videos significantly moderated the relationship between the emotionality of short videos and consumer engagement. Content released in the morning enhanced the positive impact of warmth, excitement and joy on consumer engagement, compared to that released in the afternoon. Practical implications The findings provide new insights for the dissemination of products and brand culture through short videos. The authors suggest that enterprises that use brand videos consider content matching, information relevance, storytelling and emotionality in their design. Originality/value From a broader perspective, this study constructs a new method for comprehensively evaluating short-branded video content, based on four dimensions (content matching, information relevance, storytelling and emotionality) and explores the value of these dimensions for creating social media marketing success, such as via consumer engagement.© 2023 Emerald Publishing Limited. This manuscript version is made available under the Creative Commons Attribution–NonCommercial 4.0 International (CC BY–NC 4.0) license, https://creativecommons.org/licenses/by-nc/4.0/fi=vertaisarvioitu|en=peerReviewed

Tuina combined with moxibustion for 28 cases of lung-wei insecurity-type sweating syndrome in children

目的:探讨推拿配合艾灸治疗肺卫不固型小儿汗症的临床疗效。方法:采用小儿推拿结合艾灸治疗28例肺卫不固型小儿汗症患儿,推拿隔日一次,艾灸隔三日一次; ,治疗4周后观察临床疗效。结果:推拿配合艾灸治疗肺卫不固型小儿汗证的总有效率为92.85%。结论:推拿配合艾灸治疗肺卫不固型小儿汗证疗效肯定,值; 得临床上推广应用。Objective To explore the clinical efficacy of tuina combined with; moxibustion for treatment of lung-wei insecurity-type sweating syndrome; in children. Methods Infantile tuina combined with moxibustion was; conducted for 28 cases of lung-wei insecurity-type sweating syndrome in; children. Tuina was carried out for once every other day, and; moxibustion was conducted for once every other three days. Clinical; efficacy was observed after treatment for 4 weeks. Results The total eff; ective rate of tuina combined with moxibustion for treatment of lung-wei; insecurity-type sweating syndrome in children was 92.85%. Conclusion The; efficacy of tuina combined with moxibustion for treatment of lung-wei; insecurity-type sweating syndrome in children is definite, which is; worthy of being popularized clinically.Supported by Inheritance venation and academic idea study of Huxiang; five meridians combination acupuncturemoxibustion and tuina academic; schoo

Aberrant Regulation of mRNA m6A Modification in Cancer Development

N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic messenger RNAs (mRNAs). The m6A modification in RNA can be catalyzed by methyltransferases, or removed by demethylases, which are termed m6A writers and erasers, respectively. Selective recognition and binding by distinct m6A reader proteins lead mRNA to divergent destinies. m6A has been reported to influence almost every stage of mRNA metabolism and to regulate multiple biological processes. Accumulating evidence strongly supports the correlation between aberrant cellular m6A level and cancer. We summarize here that deregulation of m6A modification, resulting from aberrant expression or function of m6A writers, erasers, readers or some other protein factors, is associated with carcinogenesis and cancer progression. Understanding the regulation and functional mechanism of mRNA m6A modification in cancer development may help in developing novel and efficient strategies for the diagnosis, prognosis and treatment of human cancers

Integrated Analysis of a Ferroptosis-Related LncRNA Signature for Evaluating the Prognosis of Patients with Colorectal Cancer

LncRNAs have been well known for their multiple functions in the tumorigenesis, development, and relapse of colorectal cancer (CRC). Accumulating studies demonstrated that the expression of lncRNAs can be regulated by ferroptosis, a biological process that has been revealed to suppress CRC progression. However, the functions and clinical implications of ferroptosis-associated lncRNAs in CRC remain largely unknown. We, herein, aim to construct a prognostic signature with ferroptosis-related lncRNAs for the prognostic estimation of CRC patients. Firstly, we identified the lncRNAs related to ferroptosis based on the RNA-Seq data of CRC from the TCGA database. The univariate and multivariate Cox analyses were then performed to establish a prognostic signature composed of eight ferroptosis-related lncRNAs (AL161729.4, AC010973.2, CCDC144NL-AS1, AC009549.1, LINC01857, AP003555.1, AC099850.3, and AC008494.3). Furthermore, we divided the CRC patients into high- and low-risk groups based on the signature and found the overall survival (OS) of patients in the high-risk group was significantly shorter than that in the low-risk group (p = 3.31 × 10−11). Moreover, the patients in the high-risk groups had shorter recurrence-free survival (RFS) (p = 6.5 × 10−3) and disease-free survival (DFS) (p = 4.27 × 10−4), as well as higher tumor recurrence rate. Additionally, we found that the oncogenic pathways were enriched in the high-risk group, whereas the ferroptosis pathway that probably repressed CRC development was enriched in the low-risk group. In summary, our signature may provide a theoretical foundation for not only accurate judgment for prognosis but also evaluation for recurrence and metastasis in CRC patients

Definitive irradiation as a first treatment strategy for primary and metastatic sites of newly diagnosed IVB cervical cancer that presented with synchronous oligometastases

Abstract Background The present study identified survival and progression-free rates and evaluated prognostic factors for IVB stage cervical cancer in patients that presented with synchronous oligometastases (sync-oligometastases) who received definitive irradiation for primary and metastatic sites. Methods The study retrospectively included 60 patients with newly diagnosed stage IVB cervical cancer. Patients received definitive radiation for both primary and metastatic sites through Volumetric Modulated Arc Therapy (VMAT) or intensity modulated radiation therapy (IMRT) followed by three dimensional-intracavitary/interstitial brachytherapy at our institution between July 2014 to December 2020. All patients were staged based on the International Federation of Gynecology and Obstetrics (FIGO) 2018 guidelines. Overall survival (OS), progression-free survival (PFS), and patient prognostic factors were analyzed. Results The 60 patients who received curative-intent irradiation for primary and metastatic sites showed a 5-year OS rate of 51.4% and a 5-year PFS rate of 25.9%. The median PFS was 52.3 months, and the median OS had not been reached. Lymphatic metastases had a better OS compared with hematogenous metastases (3-year OS rates: 57.2% vs. 20%, p = 0.017). Patients with one metastasis site showed a more favorable prognosis than patients with ≥ 2 metastases sites (3-year OS rates: 60.4% vs. 20.6%, p = 0.003). Patients that presented with tumors larger than 4 cm in diameter before treatment demonstrated a poorer prognosis (5-year OS rates: 41.2% vs. 65.2%, p = 0.029; 5-year PFS rates: 10.4% vs. 53.7%, p = 0.021). Conclusion Definitive irradiation for both primary and oligo-metastatic sites for selected IVB patients is a feasible treatment strategy. Metastatic type, number of metastatic sites, and pre-treatment tumor diameter were significant prognostic factors. Neoadjuvant chemotherapy, the lymph nodal metastatic type (supraclavicular or inguinal), and number of lymphatic metastatic sites failed to reach statistical significance as prognostic factors